Coumarin-based fluorescent probe for the detection of glutathione and nitroreductase
نویسندگان
چکیده
With this research we set out to develop a coumarin-based novel fluorescent probe NTR-AHC for the detection of biological thiols and nitroreductase (NTR). Probe was constructed by attaching NTR trigger moiety (p-nitrobenzyl) biothiol acceptor (maleic acid monoamide), core fluorophore AHC. In presence both glutathione (GSH) NTR, produced >8-fold increase in fluorescence intensity at 463 nm.
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ژورنال
عنوان ژورنال: Tetrahedron
سال: 2021
ISSN: ['0040-4020', '1464-5416']
DOI: https://doi.org/10.1016/j.tet.2020.131890